Clinical & Operational Research

MODHIP leads groundbreaking clinical and operational research that informs policy, strengthens military readiness, and improves public health outcomes across Nigeria. Research That Shapes National Health Security.

Advancing Science. Strengthening Health Systems.
Protecting Lives Through Evidence.

Overview

volunteer

MODHIP leads pioneering clinical and operational research that shapes policies, improves service delivery, and drives innovations in military and public health.

Clinical and Operational Research is a cornerstone of MODHIP’s contribution to Nigeria’s health security and military medical advancement. Through world-class research infrastructure and global partnerships, MODHIP generates locally relevant, globally credible evidence that guides:

  • Vaccine development

  • Disease surveillance

  • Treatment strategies

  • Health systems strengthening

  • Emergency outbreak response

MODHIP’s research ecosystem is built on long-standing collaboration with international and national partners including Walter Reed Army Institute of Research, U.S. Army Medical Research Directorate – Africa, World Health Organization, and Nigeria’s Federal Ministry of Health.

MODHIP operates a coordinated national research network anchored by:

  • Clinical Research Centre (CRC), Abuja – Vaccine trials and outbreak studies

  • Clinical Training & Research Centre (CTRC), Kaduna – Operational and field research

  • Defence Reference Laboratory (DRL), Abuja – Laboratory-driven clinical research and biospecimen science

These facilities support protocol-driven studies, bioanalytics, community engagement, and ethical governance.

  •  

All MODHIP research adheres to:

  • Good Clinical Practice (GCP)

  • Good Clinical Laboratory Practice (GCLP)

  • National Health Research Ethics Committee (NHREC) requirements

  • International regulatory standards

  • Robust quality assurance programs

  • Ethical principles grounded in participant safety and confidentiality

This ensures that every study meets the highest benchmarks of scientific integrity.

  •  

We strengthen Nigeria’s research workforce by offering:

  • GCP and GCLP training

  • Research methodology and protocol development

  • Data management and analysis training

  • Mentorship for young investigators

  • Field epidemiology and outbreak investigation support

These programs cultivate the next generation of military and national health researchers.

MODHIP collaborates with:

  • Walter Reed Army Institute of Research
  • U.S. Army Medical Research Directorate – Africa
  • Federal Ministry of Health Nigeria
  • Nigerian Centre for Disease Control
  • Academic institutions and global research networks
  • International donors and technical agencies
  •  

  • Military-grade discipline in research execution

  • Strong ethical and community governance

  • Integrated laboratory-clinical-field research model

  • Real-time translation of data into policy and practice

  • Global partnerships with local Nigerian leadership

MODHIP’s research has:

  • Nigeria’s First Successful Ebola Vaccine Trial conducted at CRC Abuja.
  • Multi-country WHO-facilitated and GSK-sponsored Phase 2a Ebola study.
  • Large-scale HIV and TB operational research informing national guidelines.
  • Strengthened epidemic preparedness research capacity within the Armed Forces.
  • Built sustainable research infrastructure within the military.
  • Enhanced Nigeria’s readiness against emerging infectious diseases.
  • Enabled more effective HIV treatment strategies nationwide.
  • Improved PMTCT outcomes and maternal health indicators.

These milestones positioned MODHIP as a trusted African partner in global health research.

Our Core Areas of Focus

Our Core Areas of Focus

Key Research
Focus Areas

volunteer

MODHIP delivers protocol-driven studies, bioanalytics, community engagement, and ethical governance.

MODHIP supports research under the Military HIV Research Program (MHRP), including:

  • Long-term ART treatment optimization

  • HIV drug resistance monitoring

  • Studies on viral suppression and treatment outcomes

  • HIV vaccine development pipelines

These studies aim to advance the global understanding of HIV and strengthen Nigeria’s response.

We conduct investigations and surveillance studies on:

  • TB and multi-drug resistant TB (MDR-TB)

  • Malaria

  • Viral hepatitis

  • Lassa fever, Mpox, Ebola, and emerging pathogens

  • Co-infections and co-morbidities among military personnel

This research enhances outbreak readiness and national disease control.

Our operational research identifies what works — and what needs improvement — in military hospitals and MODHIP-supported sites.

Focus areas include:

  • Service delivery optimization

  • Patient-centered care models

  • Healthcare quality improvement

  • Supply chain efficiency

  • Task shifting and workforce performance

  • Digital health systems and data-driven decision-making

Findings directly inform program design and policy implementation.

To strengthen Nigeria’s preventive health capacity, MODHIP conducts studies on:

  • PMTCT performance

  • Cervical cancer screening uptake

  • Community HIV testing effectiveness

  • IPC adherence and HAI reduction

  • Behavioral and social determinants of health

This helps reduce disease burden across diverse populations.

Through CRC and DRL, MODHIP contributes to:

  • Multi-site vaccine trials

  • Therapeutics evaluation

  • Safety and immunogenicity studies

  • Sample repository management and long-term follow-up

These efforts position Nigeria as a contributor to global scientific discovery.

Interested in Research Collaboration or Participation?

Partner With Us

volunteer

Whether you are a research institution, donor agency, academic body, or potential study participant, MODHIP welcomes collaboration to advance health science in Nigeria and beyond.